Topical Jinhuang unction combined with oral Sangqin mixture for the patients with moderate to severe acnevulgaris

Abstract

Objective To evaluate the efficacy of topical Jinhuang unction combined with oral Sangqin mixture forthe patients with moderate to severe acnevulgaris. Methods A total of 72 patients with moderate to severe acne(Pills bury grade 2 or grade 3)were included and divided into a study group and a control group by random number table method, 36 in each group. The patients were treated for 2 months in the study group with topical Jinhuang unction combined with oral Sangqin mixture, and in the control group with topical fusidic acid combined with oral Sangqin mixture. The number of lesions and the Global Acne GradingSystem(GAGS)score for each patient were obtained and evaluated. The number offollicular Propionibacterium acnes was determined with real-time fluorescence quantitative polymerase chain reaction. Results After treatment, the number of papule(28.69 ± 10.50 vs. 36.61 ± 10.10; t=3.262, P=0.002)was significantly less than that in the control group. The pustules was 1(0, 3)and the nodules was 0(0, 1)in the study group, which were significantly less than those of 3(0, 15)and 0(0, 4)in the control group(P<0.01). The GAGS scores was 13(6, 24), which was significantly less than those of 20(17, 32)in the control group significantly lower(Z=-6.482, P<0.01). The number reduction rate of follicular Propionibacterium acnes per unit area in the study group were 43.07%(-57.14%, 86.23%), which was significantly higher than that of 12.68%(-34.52%, 51.11%)in the control group(Z=-2.705, P=0.007). Conclusions Topical Jinhuang unction combined with oral Sangqin mixture may reduce the damage of the skin, decrease the numbers of papule, pustules and nodules, depress Propionibacterium acnes in patients with moderate to severe acne vulgaris. Topical Jinhuang unction combined with oral Sangqin mixture is superior to topical fusidic acid combined with oral Sangqin mixture for the treatment of moderate to severe acne vulgaris. Key words: Acne vulgaris; Administration, topical; Fusidic Acid; External application drugs(TCD); Propionibacterium acnes; Jinhuang uction; Sangqin mixture