Topical herbal application in the management of atopic dermatitis: a review of animal studies.

Younghee Yun,Inhwa Choi,Seong-Gyu Ko,Kyuseok Kim

doi:10.1155/2014/752103

Younghee Yun, Inhwa Choi + Show 2 more

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https://doi.org/10.1155/2014/752103

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Abstract

Herbs are widely used in the treatment of atopic dermatitis (AD) in Eastern Asian countries, and certain herbs regarded have anti-inflammatory properties that can help with AD. With the goal of developing a topical herbal agent for AD, we conducted a systematic review of in vivo studies of AD-like skin models for screening potential herbs. Searches were conducted from PubMed and EMBASE. After all, 22 studies were included for this review. We judged most of the domains of all studies to be at unclear risk of bias. Among 22 included studies, 21 herbs have been reported to reduce AD-like skin lesions in mouse models by suppressing Th2 cell response. Our findings may offer potential herbs for the topical application treatment of AD.

Highlights

There are many chemical substances that have been derived from plants for use as drugs, and these include some of the most utilized drugs such as aspirin, atropine, digoxin, ephedrine, morphine, quinine, and taxol
Natural sauces have only taken a secondary role in drug discovery and development after the advent of molecular biology and combinatorial chemistry
atopic dermatitis (AD) is characterized by pruritus; eczematous lesions accompanied by excessive infiltration of inflammatory cells such as lymphocytes, macrophages, and granulated mast cells in the skin lesions; eosinophilia in the peripheral blood; and high levels of serum immunoglobulin IgE

Summary

Introduction

There are many chemical substances that have been derived from plants for use as drugs, and these include some of the most utilized drugs such as aspirin, atropine, digoxin, ephedrine, morphine, quinine, and taxol. Natural sauces have only taken a secondary role in drug discovery and development after the advent of molecular biology and combinatorial chemistry. As a basis for drug development, a new interest in the role of natural sauces has been concentrated, because various “-omics” technologies allow scientists to detail the exact biological effects of natural sauces [1]. Atopic dermatitis (AD) is a chronic inflammatory skin disease with an increasing prevalence in industrialized countries. AD is characterized by pruritus; eczematous lesions accompanied by excessive infiltration of inflammatory cells such as lymphocytes, macrophages, and granulated mast cells in the skin lesions; eosinophilia in the peripheral blood; and high levels of serum immunoglobulin IgE. The pathogenesis of AD has not yet been fully understood, genetic, environmental, pharmacological, psychological, immunological, and skin barrier dysfunction factors are believed to contribute to the underlying pathogenic mechanisms [2,3,4]

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