Topical Formulations of Butterfly Pea Flower (Clitoria ternatea L.) Ethanol Extract by Ultrasound-assisted Extraction: Formulation and Antioxidant Activity Evaluation

Abstract

The antioxidant action of Butterfly pea flower (Clitoria ternatea L.) is believed to be attributed to its flavonoids, alkaloids and polyphenols components. These chemicals function as antioxidants, effectively neutralising free radicals and providing protection against skin damage caused by UV radiation. The objective of this study was to ascertain the IC50 value of butterfly pea extract and thereafter to evaluate the degree of customer preference and convenience towards pharmaceutical items. This study utilised ultrasound-assisted extraction with a solvent technique employing 96% ethanol to generate extracts. These extracts were then compounded into several topical formulations including cream, gel and face spray. Initial assessments were conducted on all compositions, encompassing organoleptic, homogeneity, pH, viscosity, specific gravity, adhesion, spreadability, wetness and irritation. This study also incorporated acceptance and customer preference as factors. The antioxidant activity of BPF extract was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) technique by estimating the IC50 value. The analysis revealed that the BPF extract had a yield of 38.75%. The IC50 values for the gel, cream and face mist preparations were 97.70, 49.14 and 73.89 ppm respectively. The cream recipe had the highest level of antioxidant activity. The determination of consumer preference has indicated that the majority of consumers favours face mist over other formulations.