Topical cyclosporine‐A in dry eye associated with chronic graft versus host disease

Abstract

SummaryGraft‐versus‐host disease (GVHD) is a major complication of bone marrow transplantation and seen in 50–70% of cases. It is a complex clinical disease with many organ and system involvement. Acute form is seen in the first 3 months after transplantation, mainly as hepatitis and chronic form is mostly seen after acute GVHD. Ocular manifestations can be classifed as anterior and posterior findings but dry eye syndrome is the most frequent ocular finding and seen in 40–90% of patients with chronic GVHD. Corneal vascularization, keratitis and perforation can be seen. Topical cyclosporine‐A might be an effective and safe treatment option in dry eye related to chronic GVHD in combination with topical steroids, autologous serum, lubricant eye drops and ointments.