Abstract
To the Editor: A 5-year-old child with molluscum contagiosum on the axillary fossae, the left elbow, the left popliteal fossa, and the right thigh was treated with imiquimiod 5% cream 3 times weekly. At each application the mother used 12.5 mg on these surfaces. Two days after the first application, the child developed a temperature of 40°C (rectal) accompanied by severe headaches; temperature decreased to normal 5 days after the first application. During these 5 days, the mother stopped the treatment. When the fever disappeared, imiquimod was applied again to the same areas. Less than 24 hours after the second treatment, the child became febrile again at 39°C, and then the fever disappeared in 1 day. Thereafter the mother applied imiquimod for a third time and the next day a 24-hour fever of 39°C appeared again. Lastly, during the fourth and last imiquimod application, once again in less than 24 hours, a febrile state of 39.5°C developed (Fig 1).
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