Abstract
Impaired wound healing is considered to be one of the severe complications associated with diabetes. Adelmidrol and trans-traumatic acid are commonly called Nevamast®. This gel consists precisely of 2% adelmidrol and 1% trans-traumatic acid. Thanks to its components, it is capable of favoring the natural process of skin re-epithelialization. This study tests the theory that topical usage of adelmidrol + trans-traumatic acid has important effects on the healing and closure of diabetic wounds in a streptozotocin (STZ)-induced diabetic mouse model. Diabetes was induced by intraperitoneal injection of STZ (60 mg/kg) in 0.01 M citrate buffer (pH 4.5) administrated for 5 consecutive days. After diabetes induction, two longitudinal incisions were made on the dorsum of the mice. The animals were killed between 6 and 12 days from wound induction. We found that diabetic mice compared to control mice presented: a retarded wound closure, characterized by an important reduction in the levels of transforming growth factor-β, plus an important increase of vascular endothelial growth factor and endothelial-type nitric oxide synthase expression, together with a reduction of adhesion molecules such as intercellular adhesion molecule-1 and P-selectin and a prolonged elevation of the levels of matrix metalloproteinase-9 and matrix metalloproteinase-2 in wound tissues. This study demonstrates that topical application of adelmidrol + trans-traumatic acid has important effects on the healing and closure of diabetic wounds in an STZ-induced diabetic mouse model.
Highlights
The term “diabetes mellitus” (DM) refers to a group of metabolic dysfunctions characterized by a high concentration of glucose in the blood
DM is caused by an elaborate interaction between environmental and genetic factors, which leads to inadequate secretion and/or diminished insulin action (Mustoe, 2004; American Diabetes, 2009)
To investigate the mechanisms through which neovascularization is promoted, after the treatment with adelmidrol + transtraumatic acid, we evaluated the levels of endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF)
Summary
The term “diabetes mellitus” (DM) refers to a group of metabolic dysfunctions characterized by a high concentration of glucose in the blood. As a consequence of the Nevamast Heals Wounds in Diabetic Mice hyperglycemia that characterizes this pathology, the complications generated can be divided into acute or long term (Brownlee, 2005). Long-term complications usually depend on the gravity and duration of diabetes. These changes affect various organs and systems and are responsible for the morbidity and mortality associated with this disease. These complications are arbitrarily divided into vascular and non-vascular (Lachin et al, 2008). Nonvascular complications, on the other hand, involve different systems including the nervous system, the gastrointestinal tract, the genitourinary system, skin’s ulcerations and scarring problems, and at last retinopathy. The incidence of infectious diseases is increased (Rask-Madsen and Kahn, 2012; Chawla et al, 2016)
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