Topical antimicroial drugs for therapy of inflammatory nasopharyngeal diseases in pediatric practice

Abstract

This article presents an overview of the clinical studies investigating the role of pathogenic bacterial flora in etiology of chronic adenoiditis in children. According to the literature, the main reason for the development of chronic diseases of the nasopharynx in children is viral and bacterial infection. The main bacterial pathogens isolated from the nasopharynx in children with chronic adenoiditis are Staphylococcus aureus, Haemophilus influenzae and Streptococcus pneumonia. However, on the basis of research it is evident that opinions of scholars differ. Significant role in formation of persistence of these pathogens in the nasopharynx in chronic adenoiditis is the ability of bacteria to biofilm formation. Bacterial biofilms as well as the identification of a large number of bacteria within the tissues of the pharyngeal tonsil determine numerous issues about the need for both systemic and topical antimicrobial therapy.