TOPICAL ANTIMICROBIAL OINTMENT AND GEL PREPARATION FROM BIOSYNTHESISED SILVER NANOPARTICLE USING TABERNAEMONTANA DIVARICATE

Abstract

Topical antimicrobials are mainly used to ght against infection caused by any micro-organism like fungi, virus and bacteria. The topical antimicrobial ointment and gel is less toxic compared to the chemical formulation. Tabernaemontana divericata have antimicrobial, antioxidant, antitumor and analgesic effect. It is known for its therapeutic effect in the healing of wound and treatment of various diseases like skin diseases, aches, ascaris, scabies, eye diseases and pain. In the present study, Silver nanoparticle was synthesised from the stem extract of Tabarnaemontana divaricata. 1mM of silver nitrate was used for the synthesis of silver nanoparticle. Ointment and gel preparations were made using biosynthesised nanoparticle and physical evaluation was carried out. Both ointment and gel forms are known to exhibit high antimicrobial activity as compared to the commercially available ointment and gel. They also have antioxidant, anticoagulation, anti-inammatory, anticancer activity and are proved to exhibit less cytotoxic effects. This may be of therapeutic value and be a widely accepted treatment modality.