Abstract
We describe two patients with fungal keratitis refractory to standard antifungal therapy whose conditions were managed with voriconazole.The first case is a patient with endophthalmitis and corneal ulcer due to Candida parapsilosis after receiving a corneal transplant. The patient was treated with amphotericin but showed no signs of improvement. Topical voriconazole, oral voriconazole, and intravitreal voriconazole yielded signs of improvement. The second case is a 63-year-old male who underwent a month of empiric treatment with 0.2% topical amphotericin for fungal keratitis but showed no signs of improvement. Treatment was then provided with 1% voriconazole. Both cases showed effective treatment with voriconazole.Voriconazole may be considered as a new method to treat fungal keratitis refractory to standard antifungal therapy.
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