Abstract
Background: Treatment of atopic dermatitis and psoriasis in children is difficult due to lack of standardized treatment guidelines and few FDA-approved treatment options. Treatments approved for adults may be used off-label in pediatric patients. Objective: This review evaluates the topical and oral treatment options available, including off-label uses, and provides a basic therapeutic guideline for pediatric atopic dermatitis and psoriasis. Methods: A PubMed review of topical and systemic treatments for pediatric psoriasis and atopic dermatitis with information regarding age, efficacy, dosing, contra-indications, adverse events, and off-label treatments. Results: The search identified seven topical and five systemic treatments that are routinely employed to treat pediatric atopic dermatitis and psoriasis. Limitations: Standardized guidelines regarding treatment choice, dosing, and long-term safety are scarce. Reviews may be subject to ascertainment bias. Conclusions: Current treatment guidelines are based on clinical experience and expert advice with few treatments officially approved for atopic dermatitis and psoriasis in children.
Highlights
Atopic dermatitis (AD) and psoriasis are dermatological conditions common in pediatric populations
This review aims to evaluate current topical and systemic treatment options available for pediatric patients with AD or psoriasis
Urea is commonly used as an additive in emollients, and is crucially important in patients with significant scaling, as the urea acts as an exfoliating agent, and allows topical anti-inflammatory agents to better absorb [9]
Summary
Atopic dermatitis (AD) and psoriasis are dermatological conditions common in pediatric populations. Detection and maintenance therapy are key to reducing flares and possibly reducing comorbidity risk Management of these chronic conditions in the pediatric population can be challenging due to the limited medications available for pediatric populations and the tendency towards nonadherence in this age group [4]. Objective: This review evaluates the topical and oral treatment options available, including off-label uses, and provides a basic therapeutic guideline for pediatric atopic dermatitis and psoriasis. Methods: A PubMed review of topical and systemic treatments for pediatric psoriasis and atopic dermatitis with information regarding age, efficacy, dosing, contra-indications, adverse events, and off-label treatments. Conclusions: Current treatment guidelines are based on clinical experience and expert advice with few treatments officially approved for atopic dermatitis and psoriasis in children
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