Abstract
Topical analgesic creams and nociception in diabetic neuropathy: towards a rationale fundament
Highlights
Since the end of last century topical analgesics are increasingly explored and discussed as serious options for treating different classes of pain [1,2,3,4,5]
Analgesic and anti-inflammatory agents used in compounded topical creams can be selected based on having a multitude of effects at different targets in the skin, influencing various biological functions related to nociception and immunity [6]
In the epidermis we find an intimate interplay between many non-neuronal cells, such as keratinocytes, with various dermal immunocompetent cells, such as dendritic cells, gamma-delta T cells and mast cells, as well as with the nerve endings in the skin [21,22]
Summary
Since the end of last century topical analgesics are increasingly explored and discussed as serious options for treating different classes of pain [1,2,3,4,5]. Analgesic and anti-inflammatory agents used in compounded topical creams can be selected based on having a multitude of effects at different targets in the skin, influencing various biological functions related to nociception and immunity [6]. This again leads to a further production of pro-inflammatory cytokines, such as interleukin-6, creating a pain-inflammation sensitization cascade [13].
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