Abstract
Background: The objective of this study was to identify the top 100 cited articles in primary aldosteronism, and examine their characteristics. Methods: Science Citation Index Expanded database was utilized to search for the top 100 cited articles published since 1900. Articles were evaluated for several characteristics, including the number of citations, authorship, country and institution of origin, publication year, journal, and study design. Results: The top 100 articles were cited between 88 and 762 times, with a median of 130. The articles were published between 1955 and 2012, with the majority of the primary aldosteronism publications (n=35) being published between 2000 and 2009. The biggest number of the top 100 cited articles (n=19) were published in the <i>Journal of Clinical Endocrinology Metabolism</i>, followed by <i>Hypertension</i> (n=9), <i>Annals of Internal Medicine </i>(n=6), and<i> Archives of Internal Medicine</i> (n=6). The United States and Italy had the most publications, whereas University of Michigan and University of Padua were the top two institutions. Observational studies were the most popular article type, followed by reviews and basic science. The impact factor of a journal was not correlated with the number of top-cited articles it published. Furthermore there was no correlation between the number of citations and the number of years since publication, authors, participating institutions, or countries involved. Conclusion: These findings will assist researchers in quickly identifying the most significant advances in the field of primary aldosteronism, as well as deciphering the characteristics of top-cited articles in this subject, and laying a basis for further research.
Highlights
Primary aldosteronism syndrome is characterized by hypertension and is caused by the autonomous secretion of aldosterone from adrenocortical lesions.Primary aldosteronism is found in over 10% of hypertensive patients and is the most frequent cause of secondary hypertension [1].Besides, it is associated with hypokalemia, renal insufficiency, and cardiovascular diseases such as coronary artery disease, stroke, myocardial infarction, cardiomegaly, arrhythmia, among others [2, 3]
(11 beta-hydroxylase), which caused the main subtype of primary aldosteronism: glucocorticoid-remediable aldosteronism, published in 1992 by Lifton RP et al in Nature
Despite the above mentioned shortcomings, this study showed the characteristics of the top-cited articles in the field of primary aldosteronism
Summary
Primary aldosteronism syndrome is characterized by hypertension and is caused by the autonomous secretion of aldosterone from adrenocortical lesions.Primary aldosteronism is found in over 10% of hypertensive patients and is the most frequent cause of secondary hypertension [1].Besides, it is associated with hypokalemia, renal insufficiency, and cardiovascular diseases such as coronary artery disease, stroke, myocardial infarction, cardiomegaly, arrhythmia, among others [2, 3]. Primary aldosteronism is found in over 10% of hypertensive patients and is the most frequent cause of secondary hypertension [1]. Numerous articles on primary aldosteronism have been published in the past decades, and the number continues to grow. It is challenging for a medical researcher or clinician to obtain a general understanding of primary aldosteronism due to the abundance of articles. Articles were evaluated for several characteristics, including the number of citations, authorship, country and institution of origin, publication year, journal, and study design. The biggest number of the top 100 cited articles (n=19) were published in the Journal of Clinical Endocrinology Metabolism, followed by Hypertension (n=9), Annals of Internal
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