Abstract
Functional tooth regeneration has shown promising therapeutic strategy. Tooth regeneration is possible by combine use of adult stem cells, growth factors, and scaffold. In recent years, researchers have explored tooth regeneration. Significant effort has been made in recent decades to identify and characterize tooth stem cells and to unravel the developmental programs which these cells follow to generate a tooth.
Highlights
Since years, dentistry has been dealing with the replacement of missing teeth with the use of synthetic materials.[1]
The regeneration of orodental tissues is dependent on appropriate signals, cells, blood supply and scaffold that are needed to target the tissue at the site of defect
Disinfection of root canal followed by the formation of blood clot matrix that trap cells capable of new tissue formation, it is not clear the regenerated tissue’s phenotype resembles dental pulp; case reports published to date do demonstrate continued root formation and the restoration of a positive response to thermal pulp testing.[2]
Summary
Dentistry has been dealing with the replacement of missing teeth with the use of synthetic materials.[1] Regenerative endodontic procedures have emerged as a viable, easy available alternative which allows root completion of immature teeth.[2] With this procedure, disadvantage of other methods can overcome (i.e., apexification and artificial apical barrier techniques) which do not allow the continuation of root development, leading to a fragile root structure and vitality of the tooth cannot be restored.[3] REPs work with the prerogative that the root canal space be free of contamination associated with a new stimulated blood supply can reestablish vascularization, enhancing root completion.[2]
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