Abstract
The effect of iontophoretic application of the 5-HT 3 receptor agonist, phenylbiguanide (PBG), on the excitation of the trigeminal spinal nucleus oralis (TSNO) neurons to tooth-pulp (TP) stimulation was examined. The PBG application inhibited the TP-evoked TSNO neuronal excitation, and this inhibition was completely blocked by co-application of a GABA A receptor antagonist, bicuculline. The results suggest that the activation of 5-HT 3 receptors elicits GABA release in the TSNO.
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