Abstract
BackgroundThe antinociceptive effect of an aqueous extract from the leaves of Toona sinensis (TS, [A. Juss., M. Roem.]) was studied using the writhing test in mice.MethodsDifferent extraction fractions from TS leaf extracts (TSL1 to TSL5) were administered orally 1 h before intraperitoneal injection of acetic acid.ResultsAfter treatment with TSL1, TSL2, TSL3, TSL4, and TSL5 at a dose of 1 g/kg, the respective writhing responses were 39.9% (P < 0.001), 19.9% (P < 0.05), 11.7% (P = 0.052), 8.1% (P = 0.188), and 11.4% (P = 0.057) lower than the control group. Mice treated with TSL1 at 1 g/kg (39.9%, P < 0.001), 0.3 g/kg (38.0%, P < 0.001), 0.1 g/kg (46.9%, P < 0.001), and 0.03 g/kg (31.1%, P < 0.001) had significantly lower writhing responses compared with control mice. A time-course experiment was performed, which involved oral administration of TSL1 (0.1 g/kg) at 0, 0.5, 1, 2, and 6 h before acetic acid intraperitoneal injection. The most effective dose of TSL1 was 0.1 g/kg orally, with the effect beginning 30 min before treatment and persisting until 6 h.ConclusionsThis study showed that TS has anti-visceral pain properties comparable with those of rofecoxib (a cyclooxygenase-2 inhibitor) and diclofenac, which suggests promise for the treatment of intractable visceral pain in humans.
Highlights
The antinociceptive effect of an aqueous extract from the leaves of Toona sinensis
Roem.]), known as Cedrela sinensis, Chinese mahogany cedar, or Chinese Toona, is a tree in the Meliaceae family that is widely distributed throughout Asia [1]
Mice treated with TSL1 at 1 g/kg (39.9%, P < 0.001), 0.3 g/kg (38.0%, P < 0.001), 0.1 g/kg (46.9%, P < 0.001), and 0.03 g/kg (31.1%, P < 0.001) had significantly lower writhing response compared with control mice, with values ranging from 31.1–46.9% inhibition
Summary
The antinociceptive effect of an aqueous extract from the leaves of Toona sinensis M. Roem.]), known as Cedrela sinensis, Chinese mahogany cedar, or Chinese Toona, is a tree in the Meliaceae family that is widely distributed throughout Asia [1]. The leaves of TS have been found to have anti-inflammatory, analgesic, and antiparasitic effects, and can act as an antidote and inhibit boil growth. TS extracts have been used to treat enteritis, dysentery, Su et al BMC Complementary and Alternative Medicine (2015) 15:70 molecules and chemokines (VCAM-1, ICAM-1, E-selectin, IL-8, and fractalkine) and may be used as an alternative treatment and prophylaxis against pandemic influenza A (H1N1) virus [12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
