Abstract
As cryo-electron microscopy (cryo-EM) enters mainstream structural biology, the demand for fitting methods is high. Here, we review existing flexible fitting methods for cryo-EM. We discuss their importance, potential concerns and assessment strategies. We aim to give readers concrete descriptions of cryo-EM flexible fitting methods with corresponding examples.
Highlights
In the past two years alone, more than 300 cryo-electron microscopy reconstructions with resolutions
Cryo-EM had shown that the apparent asymmetry is likely due to crystal lattice formation rather than intrinsic properties
Cryo-EM structures have been solved for helical polymers that cannot be crystallized in their native form because of symmetry mismatch with any crystal space group
Summary
In the past two years alone, more than 300 cryo-electron microscopy (cryo-EM) reconstructions with resolutions
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