Abstract

The impact of tonic conductance upon population activity was investigated. An extra tonic transmembrane current through GABA-activated extrasynaptic GABA A -receptors was found to control stationary asynchronous firing both quantitatively and qualitatively. Quantitative regulation consisted in alterating a current level of stationary population activity while qualitative regulation manifested itself in appearance of resilient asynchronous spiking in case GABA reversal potential exceeded a certain threshold. The study was based on a modified rate model after Wilson and Cowan and backed up with a computer simulation of an explicit network model.

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