Abstract
Tongue Hyperpigmentation Induced by Cyclophosphamide and Doxorubicin: Case Report
Highlights
Antineoplastic chemotherapy is associated with many side effects including mucosal and cutaneous manifestations
Hyperpigmentation is a rare case associated with doxorubicin and cyclophosphamide administration
Tongue hyperpigmentation can be associated with the use of certain medications such as antibiotics and bismuth
Summary
Antineoplastic chemotherapy is associated with many side effects including mucosal and cutaneous manifestations. Nail and mucosal pigmentation are examples of these side effects. We present a 46-year-old Saudi female with breast cancer who experienced hyperpigmentation of tongue secondary to doxorubicin and cyclophosphamide used for her disease. Patient complained of painless tongue hyperpigmentation that appeared after second cycle of chemotherapy administration. The tongue had normal texture with no swelling or swallowing difficulties. She was diagnosed with chemotherapy-induced tongue hyperpigmentation and advised with good mouth hygiene and antiseptic mouth wash. The dark lesions were constant in the shape, colour and size until the end of chemotherapy administration. After few months of the end of her chemotherapy treatment, the tongue hyperpigmentation disappeared spontaneously without any treatment
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