Toluene Embryopathy

J Gordon Millichap

doi:10.15844/pedneurbriefs-8-2-9

Abstract

The clinical manifestations of toluene embryopathy in 18 infants with a history of in utero exposure are reported from the Department of Pediatrics, University of Arizona College of Medicine, Tucson, and Maricopa Medical Center, Phoenix, AZ.

Highlights

Infantile spasms or myoclonic seizures were present in 16% of 30 infants with biotinidase deficiency reported from the Medical College of Virginia, Richmond, VA. (Salbert BA, Wolf B et al Neurology 1993;43:1351)
TOLUENE EMBRYOPATHY The clinical manifestations of toluene embryopathy in 18 infants with a history of in utero exposure are reported from the Department of Pediatrics, University of Arizona College of Medicine, Tucson, and Maricopa Medical Center, Phoenix, AZ
Premature birth occurred in 39%, and 9% died, 54% were small for gestational age, 52% had postnatal growth deficiency, 33% prenatal microcephaly, 67% postnatal microcephaly, 80% developmental delay, and 83% had craniofacial features similar to the fetal alcohol syndrome

Summary

Introduction

Infantile spasms or myoclonic seizures were present in 16% of 30 infants with biotinidase deficiency reported from the Medical College of Virginia, Richmond, VA. The authors advocated neonatal mass screening for early diagnosis and avoidance of neurologic damage.!Ped Neur Briefs July 1993;7:51). TOLUENE EMBRYOPATHY The clinical manifestations of toluene embryopathy in 18 infants with a history of in utero exposure are reported from the Department of Pediatrics, University of Arizona College of Medicine, Tucson, and Maricopa Medical Center, Phoenix, AZ.

Results

Conclusion