Abstract
Regulatory T (Treg) cells maintain peripheral tolerance and limit effector responses to prevent excessive immune-mediated tissue damage. However, recent research reveals that Treg cells also dampen the induction of immune responses and, thus, must be controlled to enable the effective protection against infections and cancer. Until now, this control of Treg-cell function has been believed to be by communication through cytokines or by stimulation through co-stimulatory molecules on antigen-presenting cells. However, new evidence has demonstrated that Treg cells can also sense pathogens directly through Toll-like receptors (TLRs) and, consequently, modify their behaviour. This review examines the ramifications of TLR engagement on Treg cells and conventional T cells, and discusses the potential role of TLRs on Treg cells and the consequences for disease therapy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
