Abstract
BackgroundThe immune responses to bacterial products through the pattern recognition receptor (PRR) play a pivotal role in pathogenesis of Crohn's disease. A recent study described an association between CD and some gene coding for bacterial receptor like NOD2/CARD15 gene and TLR4. In this study, we sought to determine whether TLR4 gene was associated with Crohn's disease (CD) among the Tunisian population and its correlation with clinical manifestation of the disease.Methods90 patients with CD and 80 healthy individuals are genotyped for the Asp299Gly and Thr399Ile polymorphisms by restriction fragment length polymorphism analysis.ResultsThe allele and genotype frequency of the TLR4 polymorphisms did not differ between patients and controls. The genotype-phenotype correlation permitted to show that the Thr399Ile polymorphism was associated with early onset disease.Conclusionthis study reported the absence of association between CD and TLR4 gene in the Tunisian population, but this gene could play a role in clinical expression of the disease.
Highlights
The immune responses to bacterial products through the pattern recognition receptor (PRR) play a pivotal role in pathogenesis of Crohn's disease
Some genetic markers increase the risk of ulcerative colitis (UC) or Crohn's disease (CD) while others are associated with a particular phenotypic expression like disease location and/or behaviour [1,2]
We evaluated the co-existence of Toll-like receptors 4 (TLR4) mutations and those of NOD2 and HSP70-2 genes in CD patients [12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29]
Summary
The immune responses to bacterial products through the pattern recognition receptor (PRR) play a pivotal role in pathogenesis of Crohn's disease. A recent study described an association between CD and some gene coding for bacterial receptor like NOD2/CARD15 gene and TLR4. In IBD, a disturbed hostbacteria interaction with an aberrant mucosal immune response has been observed [3,4]. This basic immunological mechanism in IBD is demonstrated by the recently described association within IBD and gene coding for receptor of bacterial products. In 2001, several studies associated CD with NOD2/CARD15 gene which coding for cytosolic receptor of bacterial muramyl dipeptides [57].
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