Abstract
A common feature of systemic autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is the production of self-reactive antibodies. The world of Toll-like receptors (TLRs) has suddenly become more interesting with the recent discovery that TLR-9 is required for the induction of autoantibodies in a mouse model of autoimmune diseases. Some autoantibodies target other antibodies and are known as rheumatoid factors (RFs) whereas in SLE autoantibodies bind chromatin or other nucleic acid or protein complexes.
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