Toll-like receptor-associated keratitis and strategies for its management.

Amandeep Kaur,Virender Kumar,Simranjeet Singh,Joginder Singh,Sourav Singla,Vijay Kumar,Shivika Datta,Niraj Upadhyay

doi:10.1007/s13205-015-0280-y

Amandeep Kaur, Virender Kumar + Show 6 more

Open Access

https://doi.org/10.1007/s13205-015-0280-y

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Journal: 3 Biotech	Publication Date: Feb 15, 2015
Citations: 45	License type: CC BY 4.0

Affiliation: Lovely Professional University

Abstract

Keratitis is an inflammatory condition, characterized by involvement of corneal tissues. Most recurrent challenge of keratitis is infection. Bacteria, virus, fungus and parasitic organism have potential to cause infection. TLR are an important class of protein which has a major role in innate immune response to combat with pathogens. In last past years, extensive research efforts have provided considerable abundance information regarding the role of TLR in various types of keratitis. This paper focuses to review the recent literature illustrating amoebic, bacterial, fungal and viral keratitis associated with Toll-like receptor molecules and summarize existing thoughts on pathogenesis and treatment besides future probabilities for prevention against TLR-associated keratitis.

Highlights

Potential targets of eye are mucosal surfaces, such as the mucosal epithelium of the cornea, and interior chambers, A
This paper focuses to review the recent literature illustrating amoebic, bacterial, fungal and viral keratitis associated with Toll-like receptor molecules and summarize existing thoughts on pathogenesis and treatment besides future probabilities for prevention against TLR-associated keratitis
Improvement in corneal cell culture models would be useful in pathogenesis of ocular diseases because it can reduce risk associated with killing of animals

Summary

Introduction

Potential targets of eye are mucosal surfaces, such as the mucosal epithelium of the cornea, and interior chambers, A. Gram-negative bacteria, Pseudomanas aeruginosa, are a major cause of bacterial keratitis in Unites States and have been found as a risk factor in contact lens wearer (Bourcier et al 2005; Green et al 2008). Some studies reported that 83 % cases of bacterial keratitis have been caused by Gram-positive bacteria like Staphylococcus species, which have been found in contact lens wearers.

Results

Conclusion