Abstract
The Toll-like receptor 4(TLR 4) polymorphism, which attenuates receptor signaling and diminishes the inflammatory response to gram-negative pathogens, is known to be associated with a decreased risk of carotid atherosclerosis. However, whether the TLR 4 polymorphism is also useful in evaluating the risk of alherothrombolic stroke is currently unknown. We investigated the association between the TLR 4 polymorphism and risk of atherothrombotic stroke using a case-control design. This study enrolled 48 stroke patients and the same number of age- and sex-matched controls. All of the subjects in this study underwent a structured interview and had their vascular risk factors assessed. With stroke patients 48 and 48 control group DNA used tlr4 gene amplification and analyzed stroke patients group and control group do not have TLR 4(Asp299Gly) polymorphism.
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