Abstract

Aim: Mutations of NOD2/CARD15 gene predispose for Crohn disease (CD) and are associated with fibrostenosing behaviour. Since NOD2/CARD15 is involved in the recognition of bacterial antigens including the pathway of toll like receptor 4 (TLR4) functional D299G polymorphism of TLR4 may be another genetic modifier for CD. In view of the large geographical differences in frequency of these genetic markers and absence of data in Central-European patients, common NOD2/CARD15 mutations and D299G-TLR4 polymorphism were determined in Hungarian CD patients.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.