Abstract
Objective To determine the relationship between Src family tyrosine kinases Fyn ex- pression and Toll-interacting protein （Tollip） in human esophageal squamous cell carcinoma （ESCC）. Methods The Tollip expression was detected in 3 cases of ESCC and compared to the unremarkable epi- thelium by Western blotting. Tollip plasmid DNA （ 1 μg） was transfected into TEl cells and the Fyn/Tollip expression was examined by Western blotting. Results The Tollip expression level was lower in ESCC group than in UNR group. Tollip decreased Fyn protein expression in TEl cells. Conclusion ToUip may act as a negative regulator of Fyn in human ESCC, and play an important role in human ESCC progress. Key words: Esophageal/neoplasms ; Carcinoma, squamous cell; Fyn ; Tollip
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