Abstract
Rhesus and owl monkeys were injected intramuscularly with 10 to 10,000 γ of Type III pneumococcal polysaccharide. The monkeys were bled weekly, and then reinoculated with the polysaccharide at suitable intervals. The antibody content of their sera was measured by radioimmunoassay and the antigen content of selected sera estimated by the inhibitory effect of the serum upon the capacity of rabbit antisera to precipitate the polysaccharide. Ten γ of the polyeaccharide immunized the monkeys. Ten thousand γ did not immunize them but instead reduced their serum antibody to very low levels. One thousand γ also reduced their serum antibody to very low levels, but not uniformly as far as 10,000 γ. These findings indicate that 1,000 to 10,000 γ of this polysaccharide appear to cause immunologic tolerance in primates.
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