Abstract
The injection of aggregate-free or tolerogenic human gamma globulin (t-HGG) induced tolerance in two lines of mice selected for high or low antibody responsiveness (high responder (H) or low responder (L) lines, respectively). In L mice, the tolerance state was very short and could no longer be obtained when the challenge injection was delayed for four weeks after tolerogenic treatment. At that time, an antibody response to t-HGG was observed in both lines; in H mice, however, this was followed by a partial tolerance state. These results and those previously obtained concerning tolerance induction to bovine serum albumin and rabbit gamma globulin in H and L mice suggest at least partial independent genetic control of antibody responsiveness and susceptibility to tolerance induction.
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