Abstract
Chronic compression (10mm Hg for 1 week) of spinal nerve roots in a dog experimental model has been shown to reduce nerve conduction velocity. Although injured, the compressed nerve roots demonstrated increased resistance to acute compression applied in addition to the chronic compression after 1 week. In the present study reduction of nerve conduction velocity induced by chronic compression recovered when the duration of compression was extended to 1 month. However, the tolerance to additionally applied compression was still present. This study provides important baseline data for continued studies of the basic mechanisms of the development of tolerance to changes in compression pressure levels in chronically compressed nerve roots.
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