Abstract
Tolerance and Inflammation at the Gut Mucosa
Highlights
The opening review article by Ramos is a critical appraisal of inflammation as a physiological phenomenon related to the development of multicellular organisms rather than solely a pathological event associated with disease and anti-infectious defense mechanisms
Murphy and coworkers reviews the role of leukocyte trafficking to the intestinal mucosa in the pathogenesis of inflammatory bowel diseases (IBDs) and the various strategies employed to target leukocyte migration as a putative therapeutic tool to control these disorders
Having demonstrated previously that DO11.10 mice could not be rendered tolerant to OVA by the oral route, the authors suggest that the altered proportions of mucosal inflammatory/regulatory T cells and intraepithelial lymphocytes (IELs) in these mice are related to resistance to oral tolerance induction
Summary
The opening review article by Ramos is a critical appraisal of inflammation as a physiological phenomenon related to the development of multicellular organisms rather than solely a pathological event associated with disease and anti-infectious defense mechanisms. The aim of this special issue is to shed some light on these mechanisms as well as to address alternative therapeutic and preventive approaches for gut inflammatory diseases. L. Weiner review the studies on the tolerogenic effects of orally administered anti-CD3 monoclonal antibody in experimental models of autoimmune diseases.
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