Abstract
The article presents the review of 61 publications. The topic is highly relevant due to the fact that clinical trials of drugs and chemotherapy regimens usually enroll adults, while children participate only in a small number of them. Often in clinical practice, anti-tuberculosis drugs are prescribed to children off-label. The frequency of adverse reactions in children varies widely depending on approaches to their reporting. The most severe and frequent adverse events are associated with liver injury. In recent years, clinical trials of fluoroquinolones, bedaquiline, and delamanid were run in pediatric patients with drug resistant tuberculosis demonstrating satisfactory tolerability and safety of these drugs.
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