Tolerability of Rofecoxib versus Naproxen

Abstract

Letters15 June 2004Tolerability of Rofecoxib versus NaproxenJeffrey R. Lisse, MD, Monica Perlman, MD, MPH, Adam B. Polis, MA, and Gregory P. Geba, MD, MPHJeffrey R. Lisse, MDFrom University of Arizona, Tuscon, AZ 85711; Scripps Clinic and Research Foundation, San Diego, CA 92037; and Merck & Co., Inc., West Point, PA 19486, and Richboro, PA 19486.Search for more papers by this author, Monica Perlman, MD, MPHFrom University of Arizona, Tuscon, AZ 85711; Scripps Clinic and Research Foundation, San Diego, CA 92037; and Merck & Co., Inc., West Point, PA 19486, and Richboro, PA 19486.Search for more papers by this author, Adam B. Polis, MAFrom University of Arizona, Tuscon, AZ 85711; Scripps Clinic and Research Foundation, San Diego, CA 92037; and Merck & Co., Inc., West Point, PA 19486, and Richboro, PA 19486.Search for more papers by this author, and Gregory P. Geba, MD, MPHFrom University of Arizona, Tuscon, AZ 85711; Scripps Clinic and Research Foundation, San Diego, CA 92037; and Merck & Co., Inc., West Point, PA 19486, and Richboro, PA 19486.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-12-200406150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:It is important to understand differences between dual cyclooxygenase-inhibiting NSAIDs and coxibs for effective use in appropriate populations. The ADVANTAGE (Assessment of Differences between Vioxx And Naproxen To Ascertain Gastrointestinal tolerability and Effectiveness) study was the largest trial to enroll patients with osteoarthritis using less restrictive entry criteria. In addition, it permitted use of low-dose aspirin during the trial and involved a sample that was characteristic of patients seen in clinical practice with typical comorbid conditions. Treatment of osteoarthritis with rofecoxib and naproxen in this setting was designed to study “real-world” conditions. Other important coxib studies, such as ...