Tolerability of Artemisia absinthium in anorexia: Targeting of neuronal appetite and satiety in zinc deficiency diet rat model

Abstract

Anorexia is a neuronal metabolic disorders induced by factors such as malnutrition and brain metabolic abnormalities during crucial developmental stages. Anorexia nervosa is a complex condition that often requires a multidisciplinary approach, involving medical, nutritional, and psychological interventions. The available medications for specific symptoms for increasing feed intake, not applicable for children and pregnant and cancer patients such as Olanzapine, and Cyproheptadine. This study looked at how Artemisia absinthium (ART) affects brain metabolic syndrome brought on zinc deficiency diet (ZDD). The investigation examined the impact of a ZDD on a rat anorexia model. The second goal is to contrast how antihistamines and Artemisia absinthe extract affect the brain functions connected to appetite. For the studies, 40 mature male rats were divided into four groups. Four groups of forty rats each were used in the experiment. Each group consists of ten rats. The following groups are included in the study: the 1st group control group, the 2nd group treated with ZDD, the 3rd group treated with ZDD concurrent with Cyproheptadine (CH), the 4th group treated with ZDD concurrent with ART. CH and ART were taken orally for 30 days. Tests on biochemical markers were conducted after the examination. The findings showed that ZDD led to reduced levels of neurotransmitters in the brain. Lower concentrations of antioxidants, monoamine, and neuropeptide Y were also found. On the other hand, groups treated with CH and ART improved in comparison to ZDD and nearly recovered in comparison to the control group. Histopathological analysis was used to confirm biochemical data. Obtained data concluded that CH and ART reduce the effects of anorexia and oxidative stress, which function as neuromodulators and promote the release of monoamines.