Abstract
The kinetics of tolbutamide-sulfaphenazole interactions were studied in rabbits. Analysis of blood level data showed that sulfaphenazole displaces tolbutamide from serum protein to increase unbound tolbutamide, which results in enhancement of the elimination of tolbutamide from the blood. This finding of enhanced elimination of tolbutamide from blood is quite different from the results of earlier researchers, who found that, in man, a marked prolongation of tolbutamide blood half-life occurred without exception. Inhibitory effects of sulfaphenazole on urinary excretion of the metabolites of tolbutamide were also observed in this study.
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