Abstract
Treatment of Yersinia ruckeri-infected juvenile coho salmon with tobramycin (TBM) revealed significant toxicity of the drug to these fish. In a group of fish receiving only 5 mg/kg/day a cumulative mortality of 100% was observed in 21 days. To verify the site of toxicity, a second study was conducted in order to histologically evaluate specific tissues and to determine dose-response characteristics. TBM produced nephrotoxicity in juvenile coho salmon at dosages only half as great as those required for an equivalent effect in mammals and did so over a much shorter treatment course. Histological examination revealed moderate to complete proximal tubule necrosis at 7.5 mg/kg every other day for 5 days. Lethality occurred at dosages as low as 2 mg/kg/day for 12 days. The data appear to indicate that salmon may be a potential model for studying the nephrotoxic potential of chemicals.
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