Tobacco use is associated with increased plasma BDNF levels in depressed patients.

Romain Colle,Laurent Becquemont,Bruno Fève,Sylvie Brailly-Tabard,Henri-Jean Aubin,Emmanuelle Corruble,Patrick Hardy,Amine Benyamina,Samuel Rotenberg,Séverine Trabado,Bruno Falissard,Céline Verstuyft

doi:10.1016/j.psychres.2016.10.012

Tobacco use is associated with increased plasma BDNF levels in depressed patients.

Romain Colle, Laurent Becquemont + Show 10 more

https://doi.org/10.1016/j.psychres.2016.10.012

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Journal: Psychiatry research	Publication Date: Oct 12, 2016
Citations: 14

Affiliation: Bicêtre Hospital, Assistance Publique – Hôpitaux de Paris, Inserm, Centre de Recherche Saint-Antoine, Sorbonne Université, Hôpital Saint-Antoine, University of Paris-Saclay, Versailles Saint-Quentin-en-Yvelines University, University of Paris-Sud, Institut Polytechnique de Paris, Centre for Research in Epidemiology and Population Health, Hôpital Paul-Brousse

#Plasma Brain Derived Neurotrophic Factor Levels #Brain Derived Neurotrophic Factor + Show 8 more

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Abstract

Since serum Brain Derived Neurotrophic Factor (BDNF) levels are higher in tobacco smokers than in non-smokers and since Major Depressive Disorder (MDD) is associated with a 2-fold increased risk of smoking, we assessed the association of smoking and plasma BDNF levels in 359 depressed MDD patients. Plasma BDNF levels were positively correlated with the magnitude of tobacco consumption (current number of cigarettes/day and number of packs/year). Accordingly, current tobacco users had significantly higher plasma BDNF levels than non-users. In further studies of MDD, peripheral measures of BDNF should take into account tobacco use.

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