Abstract
The role played by studies of tobacco mosaic virus (TMV) in the development of virology is summarized. TMV was the first virus shown to be able to pass through a bacteria-retaining filter; it was also the first virus to be crystallized, to have its morphology and structure elucidated and its coat protein sequenced. Experiments done with TMV RNA in the 1950s established that viral nucleic acid is the carrier of viral infectivity. The mechanism of self-assembly and disassembly of TMV particles is described and the antigenic properties of virions and dissociated coat protein subunits are discussed. Studies of TMV have also led to various biotechnological applications which are briefly described.
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