Abstract
The pharmacology of nicotine and other tobacco smoke fractions, and their effects on animal and human tissues, were discussed at the Second Research Conference on Tobacco and Health of the AMA-ERF, held in Scottsdale, Ariz, May 6 and 7, 1970. The majority of the 70 papers presented dealt with animal experiments. Many were concerned with work in progress or projects about to be undertaken. A selection of the findings reported is given below. In studies on the gastrointestinal pharmacology of nicotine, C. C. Hug, Jr., found a dose-dependent inhibition of contractile activity of both circular and longitudinal muscle in the gastric antrum, duodenum, ileum, and colon in intact dogs and monkeys. J. G. Forte reported that low levels of nicotine injected intravenously into rats had no effect on the gastric secretory response to cholinergic mediators, although high levels of nicotine either greatly reduced or completely abolished the hydrochloric acid secretory
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