Abstract
The exact history of tobacco use by human is still in dark. But, tobacco and its products have been used in two forms- smoked (combustible) and smokeless (non-combustible) tobacco. Pika (indigenously prepared hand-rolled bidi using a piece of leaf of kendu plant, Diospyros melanoxylon)/, bidi, cigarette, cigars and pipes etc are used as smoked items while khaini, snuff, gutkha, paan masala, betel quids (BQs) etc are used as non-smoked items. According to World Health Organizations, due to tobacco epidemic more than 8 million people are being killed in a year globally. It has also been estimated that more than 7 million of those deaths are due to direct tobacco use while around 1.2 million death cases are the result of non-smokers being exposed to second-hand smoke (SHS) [1]. Epidemiological studies have shown that there is an indomitable nexus between tobacco and cancer. Age, gender and economic status of the tobacco users, type and quantity of tobacco and above all frequency of tobacco use are some of the important conditions involved in the terrific cross-talk between tobacco and cancer.
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