Abstract
Coronel et al. reported in their recent article that there was a significant correlation between monophasic action potential (MAP) durations and activation-recovery intervals (ARIs) determined at the maximum positive slope of the positive T wave (conventional method). 1 Coronel R. de Bakker J.M. Wilms-Schopman F.J. Opthof T. Linnenbank A.C. Belterman C.N. Janse M.J. Monophasic action potentials and activation recovery intervals as measures of ventricular action potential duration: Experimental evidence to resolve some controversies. Heart Rhythm. 2006; 3: 1043-1050 Abstract Full Text Full Text PDF PubMed Scopus (154) Google Scholar The authors acknowledged that significant correlation has also been demonstrated between MAP durations and ARIs determined at the negative slope of the positive T wave (alternative method) in other studies. 2 Yue A.M. Paisey J.R. Robinson S. Betts T.R. Roberts P.R. Morgan J.M. Determination of Human Ventricular Repolarization by Noncontact Mapping Validation With Monophasic Action Potential Recordings. Circulation. 2004; 110: 1343-1350 Crossref PubMed Scopus (65) Google Scholar , 3 Gepstein L. Hayam G. Ben Haim S.A. Activation-repolarization coupling in the normal swine endocardium. Circulation. 1997; 96: 4036-4043 Crossref PubMed Scopus (57) Google Scholar , 4 Chen P.S. Moser K.M. Dembitsky W.P. Auger W.R. Daily P.O. Calisi C.M. Jamieson S.W. Feld G.K. Epicardial activation and repolarization patterns in patients with right ventricular hypertrophy. Circulation. 1991; 83: 104-118 Crossref PubMed Scopus (62) Google Scholar However, the authors had not directly compared the conventional and alternative methods of estimating ARIs at the same sites in their experiments. To The Editor—ResponseHeart RhythmVol. 4Issue 1PreviewWe thank Dr. Yue for his comments on our paper recently published in Heart Rhythm.1 The controversy on the measurement of activation recovery intervals as indicated by Dr. Yue concentrates on local electrograms with a positive T wave. Haws and Lux2 have demonstrated that the moment of fastest repolarization in transmembrane action potentials coincides with the moment of steepest rise of a local positive T wave. We have, in agreement with the established literature,2 confirmed that the maximum dV/dt of the rising part of such a positive T wave coincides with the fastest moment of repolarization of a monophasic action potential (MAP). Full-Text PDF
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