Abstract
The present paper is based on the combination of MAOI hydrazide moiety and tricyclic antidepressant moiety. This combination investigates new compounds as 1,3,4-oxadiazinoindole derivatives to find potent and safer antidepressants. Synthesis of 1,3,4-oxadiazinoindole derivatives are started from various animoacids. The sequence of synthesis reactions such as benzoylation reaction, Halo-De-hydroxylation (Nucleophilic substitution reaction), Schotten-Baumann reaction, Nucleophilic addition and finally cyclization reaction (Cyclo-De-Hydroxylation) are involved. Synthesized compounds are characterized via melting point, TLC, FT infrared spectroscopy, 1H-NMR, and mass spectroscopy techniques. All compound’s structures are confirmed.
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