Abstract
Background: 
 A prospective, non-intervention study was undertaken To study the time trend of normalization of lactate that favors survival in major trauma and sepsis in the Department of Surgery, Index Medical College Hospital and Research Centre, Indore, M.P., India for 01 year time duration. A total of 50 patients were included into study.
 Result: persistent higher LACTATE levels in non-survivors in major trauma and sepsis after 48 hours. And gradually decrease level in survivor. Thus, rising serum lactate levels suggest early prediction of shock and mortality.(p values less than 0.01)
 Above table suggest that rising serum lactate levels predict mortality in trauma and sepsis irrespective of age of patients. Because results are statistically insignificant (p > 0.01)
 Conclusion: Lactate values probably need to be followed for longer periods in critical patients even when they have tided over the present crisis. The utility of regular lactate analysis in these patients would depend on factors such as availability and cost of test also. There are no existing studies to support the above premise.
 Keywords: Normalization, Lactate, Survival, Trauma & Sepsis
Highlights
Lactate is metabolized by the liver, the kidneys, and other organs [1]
Rising serum lactate levels suggest early prediction of shock and mortality.(p values less than 0.01) Above table suggest that rising serum lactate levels predict mortality in trauma and sepsis irrespective of age of patients
Because results are statistically insignificant (p > 0.01) Conclusion: Lactate values probably need to be followed for longer periods in critical patients even when they have tided over the present crisis
Summary
Lactate is metabolized by the liver (about 60 %), the kidneys (about 30 %), and other organs [1]. The normal blood lactate concentration is around 1 mEq/l. Metabolic alterations can contribute to elevated blood lactate concentrations, including increased glycolysis, catecholamine-stimulated Na–K pump activity, alterations in pyruvate dehydrogenase activity, and reduced lactate clearance primarily as a result of liver hypoperfusion. Efforts at all levels manifestly endeavor to maintain this stream of life in the individual afflicted with trauma. A prospective, non-intervention study was undertaken To study the time trend of normalization of lactate that favors survival in major trauma and sepsis in the Department of Surgery, Index Medical College Hospital and Research Centre, Indore, M.P., India for 01 year time duration. Result: persistent higher LACTATE levels in non-survivors in major trauma and sepsis after 48 hours.
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