Abstract
Background: Platelet indices including mean platelet volume (MPV), platelet volume distribution width (PDW), plateletcrit (PCT) and platelet large cell ratio (PLCR), these indices can be measured by an inexpensive and readily available routine blood count and may be useful as a prognostic marker in patients with sepsis
 Methods: This study was planned to establish platelet indices as a prognostic marker in comparison with APACHE II and SAPS 3 score in severe sepsis patients admitted in Medical Intensive Care Unit under Department of Medicine, Jawahar Lal Nehru Medical College & Hospital, Ajmer.
 Results: In our study, higher Mean Platelet Volume(MPV) on day 7 was associated with higher APACHE II score, and this difference was statistically significant (p value-0.001). Also, higher Mean Platelet Volume (MPV) on day 7 was associated with higher SAPS III score, and this difference was statistically significant (p value-0.01).
 Conclusion: In developing countries like India platelet indices (specially MPV and PDW) measured on admission and subsequently can be used as prognostic markers in severe sepsis in emergency and critical care setup.
 Keywords: MPV, Sepsis, APACHE II, SAPS 3
Highlights
Severe sepsis is the most common cause of hospitalization in the ICU around the world, patients are often hospitalized for extended period of upto 2-3 weeks.[1]
In our study, higher Mean Platelet Volume(MPV) on day 7 was associated with higher APACHE II score, and this difference was statistically significant (p value-0.001)
Higher Mean Platelet Volume (MPV) on day 7 was associated with higher SAPS III score, and this difference was statistically significant (p value-0.01)
Summary
Severe sepsis is the most common cause of hospitalization in the ICU around the world, patients are often hospitalized for extended period of upto 2-3 weeks.[1]. Platelet indices including mean platelet volume (MPV), platelet volume distribution width (PDW), plateletcrit (PCT) and platelet large cell ratio(PLCR), these indices can be measured by an inexpensive and readily available routine blood count and may be useful as a prognostic marker in patients with sepsis.[5]. Platelet indices including mean platelet volume (MPV), platelet volume distribution width (PDW), plateletcrit (PCT) and platelet large cell ratio (PLCR), these indices can be measured by an inexpensive and readily available routine blood count and may be useful as a prognostic marker in patients with sepsis Methods: This study was planned to establish platelet indices as a prognostic marker in comparison with APACHE II and SAPS 3 score in severe sepsis patients admitted in Medical Intensive Care Unit under Department of Medicine, Jawahar Lal Nehru Medical College & Hospital, Ajmer.
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