TO STUDY THE ROLE OF C-REACTIVE PROTEIN TO PREDICT THE RISK OF PANCREATIC NECROSIS

Abstract

INTRODUCTION Acute pancreatitis is an inammation of pancreas of variable severity. Its severity varies from mild to severe attacks like necrotizing pancreatitis which has bad prognosis. C-reactive protein is an inammatory mediator synthesized in the liver and is raised in acute pancreatitis. To study t AIM OF THE STUDY he role of C-reactive protein in predicting the risk of pancreatic necrosis and other severe complications of acute pancreatitis. MATERIALS AND METHODS Ÿ Study setting: The study was conducted on patients admitted in the Department of General Medicine with features suggestive of Acute Pancreatitis. Ÿ Study period: The study was conducted between November 2021 to October 2022 Ÿ Sample size: The present study included 50 patients admitted in the Department of General Medicine with features suggestive of Acute Pancreatitis. INCLUSION CRITERIA1)Patients of any age and either sex presenting with acute pain abdomen and fourfold elevation of Serum Amylase and/or Serum Lipase. EXCLUSION CRITERIA 1)Patients with ischemic heart disease and angina 2)Patients with prior history of fever before onset of pain 3)Patients with chronic infectious diseases and known case of collagen vascular disease. RESULTS Based on 5th day CRP values 50 patients are divided into 3 groups, 1st group(n-30) CRP less than 100mg/dl, 2nd group(n-8) CRP levels between 100-200mg/dl, 3rd group(n-12) CRP levels more than 300mg/dl. The development of necrotizing pancreatitis in correlation with CRP was out of 30 patients in the 1st group, 4(13.33%) developed necrotizing pancreatitis, in the 2nd group, out of 8 patients, 4(50%) developed necrotizing pancreatitis, in the 3rd group, out of 12 patients, all 12(100%) of them developed necrotizing pancreatitis. CRP CONCLUSION levels peaked at 5th day of illness and cut off value of 150mg/dl can be taken above which pancreatic necrosis can be predicted with high probability. This value has a specicity of 80%. CRP values above 200mg/dl has a specicity of 100%.