Abstract
Background: Predominance of Type 2 diabetes mellitus (DM) is increasing globally at an alarming rate. Therapies for Type 2 DM have improved but still there is a need for new insights to limit the progression of the disease. Vitamin D deficiency has been associated with many non-skeletal disorders including Type 2 DM, suggesting a role in pathogenesis of Type 2 DM. Therefore, the present study was designed to investigate the effect of Vitamin D as an add-on therapy in patients of Type 2 DM whose glycemic status was uncontrolled with oral antidiabetic drugs. Methods: This was a before and after, open labeled study of 12 weeks duration, conducted on 50 patients of Type 2 DM and Vitamin D deficiency. These patients were given 60,000 IU of Vitamin D3 orally/week for 12 weeks in addition to oral antidiabetic drugs. Effect of Vitamin D was observed on HbAIC, fasting blood glucose (FBG), 25(OH)D and calcium levels. Results: At the end of 12 weeks, a highly significant reduction (p
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