To Study the Correlation of Vitamin D and Metabolic Syndrome in Schizophrenia

Abstract

ObjectivesSchizophrenia, a highly heterogeneous & biological disorder of the brain, is associated with biochemical, metabolic & cardiovascular derangements. Vitamin D is known to have the role as a neuro‐modulator/neuroprotection in the brain. Prevalence of metabolic syndrome in schizophrenia is very high & it further increases with the use of atypical antipsychotic drugs. The present study is conducted to correlates the association between serum levels of vitamin D and parameters of metabolic syndrome in the patient of schizophrenia.MethodsVenous blood sample was collected from 50 adult schizophrenic patients. Serum vitamin D and parameters of metabolic syndrome like waist circumference, blood pressure (systolic as well as diastolic), fasting blood glucose (FBS), triglycerides (TG) and high‐density lipoprotein (HDL) was measured. An analysis was done using the SPSS version 20.0 for Windows (Chicago, Illinois, USA). Mean and the standard deviation is calculated for the continuous variables. Pearson's correlation was used to assess the relationship between vitamin D level and parameters of metabolic syndrome.ResultsSystolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBS) and triglycerides (TG) were found to have an inverse relation with serum vitamin D level. Vitamin D level was found in the deficient category (<20 ng/dl) in most of the patients. Waist Circumference and high‐density lipoprotein (HDL) was found to have a direct correlation with vitamin D in the patient of schizophrenia of the population.ConclusionsThe study showed the possible clinical role of vitamin D level in initiating changes in the biochemical and physical parameters of metabolic syndrome in patients of schizophrenia even though the sample size is small. It might signify the role of Vitamin D in the pathogenesis of metabolic syndrome in schizophrenia.Support or Funding InformationThe present study is a part of my intramural project funded by All India Institute of Medical Sciences, Jodhpur, Rajasthan, IndiaThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.