To study the comparison of efficacy of letrozole versus clomiphene citrate for ovulation induction in infertile women with PCOS in Indian population

Abstract

Background: The aim of the study was to study the comparison of the efficacy of letrozole versus clomiphene citrate (CC) for ovulation induction in infertile women with polycystic ovary syndrome (PCOS) in Indian population. Methods: This prospective trial included 92 infertile women with PCOS. Letrozole dose of 2.5 mg/day (n = 47) or a CC dose of 100 mg/day (n = 45) was given from day 3 to day 7 of the menstrual cycle. Follicular monitoring was started from day 7 and done until the mean diameter of the largest follicle reached 18 mm, then, 5000 IU of human chorionic gonadotropin (HCG) was given. Intrauterine insemination was done in two sittings, 24 and 48 hours after HCG. Statistical testing was conducted with SPSS 17.0. Results: The clinical profile of patients belonging to both groups were comparable. The number of follicles ≥18 mm on the day of HCG was 1.11 ± 0.43 for the letrozole group and 2.53 ± 1.10 for the CC group (P