TO STUDY THE ASSOSIATION BETWEEN SERUM IRON AND FERRITIN LEVEL WITH GALLSTONE DISEASE

Abstract

INTRODUCTION: Gallstone disease is a common clinical condition affecting the adult population of both sexes. Iron deciency was found to be a new parameter in aetiology of gallstones[5, 6,7]. Iron deciency has been shown to alter the activity of several hepatic enzymes, leading to increased gallbladder cholesterol saturation and promotion of cholesterol crystal formation[8, 9]. Iron acts as a coenzyme for nitric oxide synthetase (NOS), which synthesizes nitric oxide (NO) important for the maintenance of gallbladder tone and normal relaxation [10, 11]. METHOD: Prospective case control study was conducted In Dr.B.R.A.M. Hospital, Raipur On January 2020 to December 2020. sample size was for case is 60 and for control 60 taken On the basis of inclusion and exclusion criteria . patient sonological conrmed and estimate the serum iron and ferritin level . Data are analyzed with descriptive statistical principals RESULT: 31.67% patient of cholelithiasis have serum iron level below normal value .In control group 21.67% participants have normal serum iron level ( P value = 0.21) 33.33% cases have serum ferritin level below normal range and18.33% of control group have serum ferritin level below normal range ( P value = 0.06 ) CONCLUSION: gallstone are more prevalent in female population than males . low serum iron was not signicantly found in both case and control group with relation to cholelithiasis. low serum ferritin level not signicantly found both in case and control group