Abstract
Background: Pain is the most common reason for physician consultation in most countries. It is a major symptom in many medical conditions, and can interfere with a person's quality of life and general functioning. Acute pain is usually managed with medications such as analgesics and anesthetics. Cinnarizine is a piperazine derivative and Tramadol is an opioid analgesic. Cinnarizine is also a calcium channel blocker. So, in the present study an attempt has been made to access the antinociceptive activity of Cinnarizine alone & in combination with standard drug Tramadol with the hope of pharmacological synergism and better relief from pain.
 Material & Methods: 4 rats in 6 groups were weighed & colour coded. Basal reaction time to radiant heat was taken. Tail withdrawal time was recorded as the end point. Reaction time was taken at 0, 30 & 60 minutes on day 0, 7, 14, 21 & 28.
 Result: All observation were done by the ANOVA followed by post hoc Tukey’s. It is seen that Cinnarizine alone (in both doses) has antinociceptive activity but that is not statistically significant. But when it is given along with Tramadol it potentiates antinociceptive activity of Tramadol which is statistically significant.
 Conclusion: The result of this study conclude that Cinnarizine alone has antinociceptive activity in both doses (i.e 2.5mg/kg & 5mg/kg) but it is statistically not significant. Tramadol shows higher antinociception with Cinnarizine in dose of 5mg/kg than with 2.5mg/kg.
 Keywords: Antinociception, Cinnarizine, Tramadol, Tail flick test, Albino rats
Highlights
Pain is the most common reason for physician consultation in most countries.[1,2] It is a major symptom in many medical conditions, and can interfere with a person's quality of life and general functioning.[3]
In the present study an attempt has been made to access the antinociceptive activity of Cinnarizine alone & in combination with standard drug Tramadol with the hope of pharmacological synergism and better relief from pain
We found that cinnarizine induced an antinociceptive effect alone & in combination with Tramadol
Summary
Pain is the most common reason for physician consultation in most countries.[1,2] It is a major symptom in many medical conditions, and can interfere with a person's quality of life and general functioning.[3]. Pain is the most common reason for physician consultation in most countries It is a major symptom in many medical conditions, and can interfere with a person's quality of life and general functioning. In the present study an attempt has been made to access the antinociceptive activity of Cinnarizine alone & in combination with standard drug Tramadol with the hope of pharmacological synergism and better relief from pain. It is seen that Cinnarizine alone (in both doses) has antinociceptive activity but that is not statistically significant. Conclusion: The result of this study conclude that Cinnarizine alone has antinociceptive activity in both doses (i.e 2.5mg/kg & 5mg/kg) but it is statistically not significant. Tramadol shows higher antinociception with Cinnarizine in dose of 5mg/kg than with 2.5mg/kg.
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