Abstract
In this study a simple, robust and accurate RP-HPLC was developed and validated for the force degradation study of ozenoxacin as per ICH guidelines. Chromatographic separation and elution of peak was achieved by isocratic elution on agilant – 1260 infinite II HPLC system. An analysis C18X150X4.6mm 5mm, eclipse XDB column was used at flow rate 1ml/min in the mobile phase ratio methanol: 10 mM (adjusted pH -3 in the ratio of 42:52 %v/v at wavelength 250 nm and the temperature 25ºc. The force degradation study was performed on ozenoxacin under acidic, basic, oxidation, thermal, photodegradation,. The result obtained from the experiments was proved that the developed method suitable for routine analysis.
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